Spray Freezing Coating on the Carrier Particles for Powder Preparation

Preparation of dry powder inhalation by surface treatment of lactose carrier particles.

An attempt was made to produce carrier particles for dry powder inhalations by the surface treatment of lactose particles with aqueous ethanol solution. Drug/carrier powder mixtures were prepared consisting of lactose carriers with different particle surface properties and micronized salbutamol sulfate. These powder mixtures were aerosolized by Spinhaler, and in vitro deposition properties of s...

Spray-freeze-drying of nanosuspensions: the manufacture of insulin particles for needle-free ballistic powder delivery.

The feasibility of preparing microparticles with high insulin loading suitable for needle-free ballistic drug delivery by spray-freeze-drying (SFD) was examined in this study. The aim was to manufacture dense, robust particles with a diameter of around 50 microm, a narrow size distribution and a high content of insulin. Atomization using ultrasound atomizers showed improved handling of small li...

Analysis of the impact velocity of powder particles in the cold-gas dynamic-spray process

While built on a sound physical foundation, isentropic, one-dimensional models generally used to analyze the dynamics of dilute two-phase (feed-powder particles suspended in a carrier gas) flow during the cold-gas dynamic-spray process, require the use of numerical procedures to obtain solutions for the governing equations. Numerical solutions, unfortunately, do not enable an easy establishment...

Optimal Trajectory Planning for Spray Coating

Spray-painting Motion Planning and Quality Analysis in Powder Coating Systems

The paper reports results on the automation of the spray-painting process in industrial powder coating plants. The automation of the spray-painting process requires a painting model and the definition of appropriate metrics for painting task validation. Two main topics are addressed in the paper: motion planning of paint deposition and paint quality analysis. A paint quality function is formula...